Does activation of midbrain dopamine neurons promote or reduce feeding?
L Boekhoudt, TJM Roelofs, JW De Jong… - International Journal of …, 2017 - nature.com
Background: Dopamine (DA) signalling in the brain is necessary for feeding behaviour, and
alterations in the DA system have been linked to obesity. However, the precise role of DA in
the control of food intake remains debated. On the one hand, food reward and motivation are
associated with enhanced DA activity. On the other hand, psychostimulant drugs that
increase DA signalling suppress food intake. This poses the questions of how endogenous
DA neuronal activity regulates feeding, and whether enhancing DA neuronal activity would …
alterations in the DA system have been linked to obesity. However, the precise role of DA in
the control of food intake remains debated. On the one hand, food reward and motivation are
associated with enhanced DA activity. On the other hand, psychostimulant drugs that
increase DA signalling suppress food intake. This poses the questions of how endogenous
DA neuronal activity regulates feeding, and whether enhancing DA neuronal activity would …
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